Carly's old friend, Missy Robinson (Haley Ramm), comes back into her life, making Sam feel left out. After a series of events unfold in which Sam is a victim of "accidentally" being sent to a piñata factory rather than a rendezvous place, her phone being dropped in a pitcher of Wahoo Punch, and receiving Foreign Rancid Chocolate from Missy, which causes her to get violently ill, she believes that Missy is out to get her. Carly thinks Sam may be jealous or paranoid, so she decides to arrange a truce between the two girls at the Groovy Smoothie.
However, while Carly attempts to gather more smoothies from the counter, Missy exposes her true colors when she admits to Sam that she did do horrible things to her on purpose so she can reclaim her position as Carly's one and only best friend. Sam soon realizes that her feelings towards Missy are not motivated by jealousy, and despite her threats, Missy uses her now justified "paranoia" against her, claiming that if Sam beats her up, it will only turn Carly against her.
Sam then attempts to get help from Freddie, only to be quickly turned down. However before walking away, she makes him realize that this was the first time she has ever asked for his help, further showing the seriousness of her situation (If it weren't so serious, she would have never turned to Freddie).Missy wins the six-month-long "School at Sea" program and states that she no longer needs to sabotage Sam, which Carly coincidentally overhears. Carly reaffirms that Sam is her only best friend. Missy leaves and the two girls make up.
Later on, as Freddie helps Carly between classes, Wendy approaches her and reveals that Freddie actually won the "School at Sea" contest and gave the trip to Missy (despite his effort to keep this revelation from Carly), who now realizes that he secretly decided to help Sam in an effort to bring the girls back together again. After he finally admits that he did, Carly reveals that Missy used to suffer from seasickness. The episode ends to reveal that this problem hasn't completely disappeared and that the cruise she's on is actually a cargo ship.
SubplotSpencer prepares for a camping trip with Socko, two girls they met in a junkyard, and Socko's grandmother (to scare away bears). However, an old enemy of his, Chuck Chambers, traps him down in the basement.
Chuck says that Spencer got him grounded for two days (for playing racquetball in the Bushwell Plaza lobby despite Spencer telling him not to in iHurt Lewbert), and as revenge, he would keep Spencer prisoner for two days. Chuck takes Spencer's cell phone away and squirts him with an unknown fluid whenever Spencer talks too much or tries to escape.
Eventually after two days, Earl Chambers discovers them, grounds Chuck again, and drags him up the stairs. Spencer laughs and then panics when he realizes that they left him locked in the basement. It is unknown how Spencer was finally able to escape.
- Haley Ramm is a real-life best friend of Miranda Cosgrove.
- The main plot for this episode is similar to that of the Zoey 101 episode, "Son of a Dean", in which Zoey's roommates accuse Zoey's boyfriend Lance of rigging a raffle so they could go to a movie premiere together.
- This episode marks the second appearance of Chuck Chambers.
- Spencer references iMeet Fred when he asked Chuck if he would accept an ostrich as to get him out of the chain locks, meaning he could still have the ostrich.
- From this episode onward, the phone that Sam stole from Missy Robinson has now become her phone (Sam and Missy had the same phone).
- Sam states the chocolate that expired in 1992 was older than the Fresh Prince of Bel-Air; however, Fresh Prince first aired in 1990. She is possibly referring to its end.
- This episode aired as part of Nickelodeon's "Double Trouble Night."
- This is one of the are times in the series where Freddie/Nathan wears shorts instead of pants for almost the whole episode.
- The yellow purse that Missy carries around is exactly the same purse that Sam carries around in iMake Sam Girlier.
- When Chuck is playing his video games, the music playing from them is exactly the same melody from Pak-Rat in iStage an Intervention, and appears to be playing on a PSP.
- The subplot is very similar to the main plot of iPsycho, where Nora trapped Carly, Sam, and Freddie for about a day.
- In this episode, Freddie states that Sam isn't his friend, but in iMake Sam Girlier, an earlier episode, Freddie said that he and Sam are really close friends (he was most likely angry and couldn't control himself).
- This is one of the few episodes where a character (more than one character) have a near-death experience.
- When Carly and Missy walk down to the Ridgeway hallway, they pass a red-haired boy holding a brown paper bag, who Carly identifies as Kevin. She tells Missy that if Kevin asks her if she wants to see his onion ring, she should just say no. If you watch the paper bag closely, you can actually see it move. On his blog, Dan Schneider complimented the post-production team for this effect.
- In the "Fun Facts" for iReunite With Missy, Dan Schneider remarked that one day, he would get around to asking the person who does the set dressing why there are two pump bottles of lotion on top of the microwave in Carly and Spencer's kitchen.
- Carly said she had only one best friend, but she actually has two best friends, as she said in iThink They Kissed (meaning Sam and Freddie)
- Right after Spencer gets pinned under the junk in the storage locker he pushes a white hexagonal box with lid right out of the way. However after the close-up shot of his cell-phone showing that Socko is calling the lid to that box has reappeared next to him. Then when Chuck is locking Spencer in the locker the whole box with lid has reappeared next to him.
- It is unknown how Spencer got out of the basement.
- But as Sam and Carly had been best friends before meeting Freddie and since both of them are girls & as she probably talks to Sam about things she couldn't talk about to Freddie, Carly probably considers Sam being her BFF and Freddie 'only' being one of her best friends. Also, things could have changed before iThink They Kissed.
- Sam asked for Freddie's help before in iMight Switch Schools. But it was never said she never asked for his help.
View Gallery for this episode here.
[Carly and Missy squeal and hug repeatedly]
Sam: You guys aren't gonna do that every day, right?
Sam: [sick after eating expired chocolates] I feel like butt!
Sam: Remember that time you dared me to lick the swing set?
Freddie: No, I said, "Sam, don't lick the swing set," and you said, "Don't tell me what to do, Benson," and then you licked the swing set.
Carly: [about the expiration date of a box of chocolates]I can't read this. It's written in... foreign.
Sam: Well I looked it up, it says 1992. That chocolate's older than the Fresh Prince of Bel Air!
Carly: [about Sam being paranoid] And last year you were sure Gibby was a mermaid.
Sam: He hates wearing shirts! Coincidence?
Freddie: You know, maybe Carly's right. Maybe you're just jealous of Missy!
Sam: Okay, just... forget it. Don't believe me.
Freddie: [sighs] Tell me one reason why I should believe you.
Sam: 'Cause I came here. [Freddie shruggs] Have I come here for help before? For anything?
Carly: No, you care about Sam!
Freddie: Well... she was really upset.
Carly: And you said Sam wasn’t your friend!
Freddie: Yeah, whatever...
Carly: Yeah, whatever! *pokes Freddie*
Freddie: Ahrh, stop! I just hate that that nasty Missy gets to live it up on a six month cruise. Carly: Yeah, well when we were little, she used to get really sea sick, but I'm pretty sure she got over that. Freddie: Yeah too bad!
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