If you see this interview with Jim Parsons, you'll see some scenes where he appears. The scenario is the very same as the scenario of the shot where sam screams "Have I losy my mind!?" in the iLost my mind promo. And in the shot where Freddie says to sam: "Can we talk about the kiss?", the bedroom where Sam is doesn't look like a house's bedroom. There is a paper (maybe a medical record) hanging in the door and there are a los of paintings around (painting is a favored way for expressing and taking out emotions) so she might be interned in this psychological hospital at the beginning of the episode and there they meet Jim Parsons character. Of course, this is only a guessing. I do not know what the real connection might be.